Amoxicillin250 Oral Suspension 250mg/5ml is a semi-synthetic penicillin (beta-lactam antibiotic) that inhibits one or more enzymes (often referred to as penicillin-binding proteins, PBPs) in the biosynthetic pathway of bacterial peptidoglycan, which is an integral structural component of the bacterial cell wall. Inhibition of peptidoglycan synthesis leads to weakening of the cell wall, which is usually followed by cell lysis and death.
Amoxicillin is susceptible to degradation by beta-lactamases produced by resistant bacteria and therefore the spectrum of activity of amoxicillin alone does not include organisms which produce these enzymes.
Pharmacokinetic/pharmacodynamic relationship: The time above the minimum inhibitory concentration (T>MIC) is considered to be the major determinant of efficacy for amoxicillin.
Mechanisms of resistance: The main mechanisms of resistance to amoxicillin are Inactivation by bacterial beta-lactamases.
Alteration of PBPs, which reduce the affinity of the antibacterial agent for the target.
Impermeability of bacteria or efflux pump mechanisms may cause or contribute to bacterial resistance, particularly in Gram-negative bacteria.
The prevalence of resistance may vary geographically and with time for selected species, and local information on resistance is desirable, particularly when treating severe infections. As necessary, expert advice should be sought when the local prevalence of resistance is such that the utility of the agent in at least some types of infections is questionable.
Key Features of Amoxicillin 250mg/5ml Oral Suspension:
- Active Ingredient: Amoxicillin 250mg per 5ml of oral suspension.
- Broad-Spectrum Antibiotic: Effective against a wide range of both Gram-positive and Gram-negative bacteria.
- Convenient Dosage: The liquid form makes it easy to administer, especially for children or patients who have difficulty swallowing pills.
- Common Indications: Used to treat infections like:
- Respiratory infections (e.g., pneumonia, bronchitis)
- Ear infections (e.g., otitis media)
- Skin and soft tissue infections
- Urinary tract infections (e.g., cystitis, pyelonephritis)
- Effective Action: Amoxicillin works by interfering with the bacteria’s ability to form cell walls, which leads to bacterial death and infection resolution.
- Well-Tolerated: Generally well-tolerated with a low risk of side effects when used as prescribed.
- Administration: Oral suspension form is easy to use, particularly for children or those who cannot take tablets.
Amoxicillin 250mg/5ml Oral Suspension is an effective and easy-to-administer antibiotic, providing a reliable treatment option for a variety of bacterial infections.
Indications for Amoxicillin 250mg/5ml Oral Suspension:
Amoxicillin Oral Suspension is indicated for the treatment of the following infections in adults and children:
- Acute bacterial sinusitis
- Acute otitis media
- Acute streptococcal tonsillitis and pharyngitis
- Acute exacerbations of chronic bronchitis
- Community acquired pneumonia
- Acute cystitis
- Asymptomatic bacteriuria in pregnancy
- Acute pyelonephritis
- Typhoid and paratyphoid fever
- Dental abscess with spreading cellulitis
- Prosthetic joint infections
- Helicobacter pylori eradication in peptic (duodenal and gastric) ulcer disease.
- Lyme disease
- Amoxicillin250 Oral Suspension 250mg/5ml is also indicated for the prophylaxis of endocarditis.
- Consideration should be given to official guidance on the appropriate use of antibacterial agents.
Dosage & Administration:
The dose of Amoxicillin Oral Suspension that is selected to treat an individual infection should take into account:
– The expected pathogens and their likely susceptibility to antibacterial agents.
– The severity and the site of the infection
– The age, weight and renal function of the patient; as shown below
The duration of therapy should be determined by the type of infection and the response of the patient, and should generally be as short as possible. Some infections require longer periods of treatment.
Adults and children ≥ 40kg:
(A) Acute bacterial sinusitis
Dose – 250 mg to 500 mg every 8 hours or 750 mg to 1 g every 12 hours
(B) Asymptomatic bacteriuria in pregnancy
Dose – 250 mg to 500 mg every 8 hours or 750 mg to 1 g every 12 hours
(C) Acute pyelonephritis
Dose – For severe infections 750 mg to 1 g every 8 hours
(D) Dental abscess with spreading cellulitis
Dose – For severe infections 750 mg to 1 g every 8 hours
(E) Acute cystitis
Dose – Acute cystitis may be treated with 3 g twice daily for one day
(F) Acute otitis media, Acute streptococcal tonsillitis and pharyngitis, Acute exacerbations of chronic bronchitis.
Dose – 500 mg every 8 hours, 750 mg to 1g every 12 hours, For severe infections 750 mg to 1 g every 8 hours for 10 days
(G) Community acquired pneumonia
Dose – 500 mg to 1 g every 8 hours
(H) Typhoid and paratyphoid fever
Dose – 500 mg to 2 g every 8 hours
(I) Prosthetic joint infections
Dose – 500 mg to 1 g every 8 hours
(J) Prophylaxis of endocarditis
Dose – 2 g orally, single dose 30 to 60 minutes before procedure
(K) Helicobacter pylori eradication
Dose – 750 mg to 1 g twice daily in combination with a proton pump inhibitor (e.g. omeprazole, lansoprazole) and another antibiotic (e.g. clarithromycin, metronidazole) for 7 days.
(L) Lyme disease
Dose – Early stage: 500 mg to 1 g every 8 hours up to a maximum of 4 g/day in divided doses for 14 days (10 to 21 days)
Late stage (systemic involvement): 500 mg to 2 g every 8 hours up to a maximum of 6 g/day in divided doses for 10 to 30 days.
Children weighing < 40 kg
Children may be treated with Amoxicillin Capsules, dispersible tablets suspensions or sachets.
Amoxicillin Paediatric Suspension is recommended for children under six months of age.
Children weighing 40 kg or more should be prescribed the adult dosage.
Recommended doses:
(A) Acute bacterial sinusitis
Dose – 20 to 90 mg/kg/day in divided doses
(B) Acute otitis media
Dose -20 to 90 mg/kg/day in divided doses
(C) Community acquired pneumonia
Dose – 20 to 90 mg/kg/day in divided doses
(D) Acute cystitis
Dose – 20 to 90 mg/kg/day in divided doses
(E) Acute pyelonephritis
Dose – 20 to 90 mg/kg/day in divided doses
(F) Dental abscess with spreading cellulitis
Dose – 20 to 90 mg/kg/day in divided doses
(G) Acute streptococcal tonsillitis and pharyngitis
Dose – 40 to 90 mg/kg/day in divided doses
(H) Typhoid and paratyphoid fever
Dose – 100 mg/kg/day in three divided doses
(I) Prophylaxis of endocarditis
Dose – 50 mg/kg orally, single dose 30 to 60 minutes before procedure
(J) Lyme disease
Dose – Early stage: 25 to 50 mg/kg/day in three divided doses for 10 to 21 days, Late stage (systemic involvement): 100 mg/kg/day in three divided doses for 10 to 30 days
Elderly : No dose adjustment is considered necessary.
Adults and children ≥ 40 kg – 15 mg/kg/day given as a single daily dose. Prior to haemodialysis one additional dose of 15 mg/kg should be administered. In order to restore circulating drug levels, another dose of 15 mg/kg should be administered after haemodialysis. In patients receiving peritoneal dialysis Amoxicillin maximum 500 mg/day.
Precautions:
Hypersensitivity reactions : Before initiating therapy with any penicillin, careful inquiry should be made concerning previous hypersensitivity reactions to penicillins, cephalosporins, or other beta-lactam agents.
Serious and occasionally fatal hypersensitivity (anaphylactoid) reactions have been reported in patients on penicillin therapy. These reactions are more likely to occur in individuals with a history of penicillin hypersensitivity and in atopic individuals. If an allergic reaction occurs, amoxicillin therapy must be discontinued and appropriate alternative therapy instituted.
Non-susceptible microorganisms : Amoxicillin is not suitable for the treatment of some types of infection unless the pathogen is already documented and known to be susceptible or there is a very high likelihood that the pathogen would be suitable for treatment with amoxicillin. This particularly applies when considering the treatment of patients with urinary tract infections and severe infections of the ear, nose and throat.
Convulsions : Convulsions may occur in patients with impaired renal function or in those receiving high doses or in patients with predisposing factors (e.g. history of seizures, treated epilepsy or meningeal disorders.
Renal impairment : In patients with renal impairment the dose should be adjusted accordingly to the degree of impairment.
Skin reactions : The occurrence at the treatment initiation of a feverish generalised erythema associated with pustula may be a symptom of acute generalised exanthemous pustulosis. This reaction requires amoxicillin discontinuation and contra-indicates any subsequent administration.
Amoxicillin should be avoided if infectious mononucleosis is suspected since the occurrence of a morbilliform rash has been associated with this condition following the use of amoxicillin.
Interactions With Other Medicaments : Probenecid, Allopurinol, Tetracyclines, Methotrexate.
Pregnancy : Animal studies do not indicate direct or indirect harmful effects with respect to reproductive toxicity. Limited date on the use of amoxicillin during pregnancy in humans do not indicate an increased risk of congenital malformations. Amoxicillin may be used in pregnancy when the potential benefits outweigh the potential risks associated with treatment.
Breastfeeding : Amoxicillin is excreted into the breast milk in small quantities with the possible risk of sensitisation. Consequently, diarrhoea and fungus infection of the mucous membranes are possible in the breast-fed infant, so that breast-feeding might have to be discontinued. Amoxicillin should only be used during breast-feeding after benefit/risk assessment by the physician in charge.
Fertility : There are no data on the effects of amoxicillin on fertility in humans. Reproductive studies in animals have shown no teratogenic effects on fertility.
Keep The Medicine Out Of The Reach Of Children.
Side Effects:
- Nausea
- Diarrhoea
- Skin rash
- Vomiting
- Urticaria and pruritus.
NOTE: Most side effects are temporary and go away on their own, but see your doctor if they last or cause concern.
How to Store Amoxicillin 250mg/5ml Oral Suspension:
- Store at a temperature not exceeding 30°C.
- Protect from light.
Why Choose Amoxicillin 250mg/5ml Oral Suspension From Regen Global Pharma?
Choosing Amoxicillin 250mg/5ml Oral Suspension from Regen Global Pharma offers several key advantages:
- High-Quality Assurance: Produced by Regen Global Pharma, known for its commitment to producing safe, effective, and high-quality medicines that meet rigorous standards.
- Broad-Spectrum Antibiotic: Effectively treats a wide range of bacterial infections, including respiratory, urinary tract, ear, and skin infections, providing comprehensive treatment options.
- Convenient Liquid Form: The oral suspension form is easy to administer, making it ideal for children or individuals who have difficulty swallowing tablets, ensuring accurate and comfortable dosing.
- Trusted Brand: Regen Global Pharma is trusted for producing reliable medications that healthcare providers and patients can count on for effective treatment.
- Well-Tolerated: Amoxicillin is generally well-tolerated, with a low incidence of side effects when used correctly, making it a safe option for most patients.
- Fast Acting: Amoxicillin works quickly to reduce infection symptoms, promoting faster recovery and alleviating discomfort.
- Affordable and Accessible: Offering an affordable solution without compromising on quality, making it accessible to a wide range of patients.
Choosing Amoxicillin 250mg/5ml Oral Suspension from Regen Global Pharma ensures effective, safe, and convenient treatment for bacterial infections with the assurance of a trusted brand.Disclaimer: The information provided on this website is for informational purposes and is not intended as a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified healthcare provider with any questions you may have regarding a medical condition. Do not disregard professional medical advice or delay in seeking it.
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