Levofloxacin Infusion 500mg/100mL is a broad-spectrum antibiotic used to treat a variety of bacterial infections. As a fluoroquinolone, it works by inhibiting bacterial DNA replication, effectively stopping bacterial growth. This intravenous formulation is ideal for hospitalized patients who need rapid action for serious infections, including:

• Respiratory tract infections (e.g., pneumonia, bronchitis)
• Urinary tract infections
• Skin and soft tissue infections
• Intra-abdominal infections

Levofloxacin 500mg/100mL infusion offers fast, effective treatment, especially when oral medication is not an option, ensuring high drug concentrations in tissues and quick therapeutic effects.

Key Features of Levofloxacin Infusion 500mg/100ml:

• Broad-Spectrum Antibiotic:
• Effective against a wide range of both gram-positive and gram-negative bacteria, including pathogens like Streptococcus pneumoniae, Escherichia coli, and Pseudomonas aeruginosa.
• Potent Action:
• Inhibits bacterial DNA gyrase and topoisomerase IV, essential enzymes for bacterial DNA replication, leading to bacterial cell death.
• IV Formulation:
• Delivered intravenously for rapid absorption, making it suitable for hospitalized patients or those who can’t take oral medications.
• Versatile Indications:
• Used to treat severe infections such as pneumonia, urinary tract infections, skin infections, and intra-abdominal infections.
• Quick Therapeutic Effect:
• Provides high tissue concentrations quickly, ensuring effective treatment for serious and life-threatening infections.
• Well-Tolerated:
• Generally well-tolerated, with a favorable safety profile, though common side effects may include gastrointestinal upset or headache.
• Convenient Dosing:
• 500mg/100mL infusion offers straightforward dosing for healthcare providers to administer with ease.

It’s a reliable, fast-acting option for treating a wide range of infections in critical care settings.

Indications for Levofloxacin Infusion 500mg/100ml:

Therapeutic indications Levofloxacin Infusion 500mg/100mL is indicated in adults for the treatment of the following infections. 

• Community-acquired pneumonia
• Complicated skin and soft tissue infections For the above-mentioned infections Levofloxacin Infusion 500mg/100mL should be used only when it is considered inappropriate to use antibacterial agents that are commonly recommended for the initial treatment of these infections.
• Pyelonephritis and complicated urinary tract infections. Chronic bacterial prostatitis.
• Inhalation Anthrax: postexposure prophylaxis and curative treatment Consideration should be given to official guidance on the appropriate use of antibacterial agents.

Dosage & Administration:

Levofloxacin Infusion 500mg/100ml is administered by slow intravenous infusion once or twice daily. The dosage depends on the type and severity of the infection and the susceptibility of the presumed causative pathogen. Treatment with Levofloxacin Infusion 500mg/100mL after initial use of the intravenous preparation may be completed with an appropriate oral presentation according to the SPC for the film-coated tablets and as considered appropriate for the individual patient. Given the bioequivalence of the parenteral and oral forms, the same dosage can be used. Posology The following dose recommendations can be given for Levofloxacin Infusion 500mg/100mL: Dosage in patients with normal renal function (creatinine clearance > 50 ml/min).

Treatment duration includes intravenous plus oral treatment. The time to switch from intravenous to oral treatment depends on the clinical situation but is normally 2 to 4 days. Special populations: Impaired renal function (creatinine clearance ≤ 50 ml/min) 1No additional doses are required after haemodialysis or continuous ambulatory peritoneal dialysis (CAPD). Impaired liver function: No adjustment of dose is required since levofloxacin is not metabolised to any relevant extent by the liver and is mainly excreted by the kidneys.

Elderly population: No adjustment of dose is required in the elderly, other than that imposed by consideration of renal function. 

Paediatric population: Levofloxacin Infusion 500mg/100mL is contraindicated in children and growing adolescents.

Method of administration: Levofloxacin Infusion 500mg/100mL is only intended for slow intravenous infusion; it is administered once or twice daily. The infusion time must be at least 30 minutes for 250 mg or 60 minutes for 500 mg Levofloxacin Infusion 500mg/100mL.

Precautions:

Methicillin-resistant S. aureus are very likely to possess co-resistance to fluoroquinolones, including levofloxacin. Therefore levofloxacin is not recommended for the treatment of known or suspected MRSA infections unless laboratory results have confirmed susceptibility of the organism to levofloxacin (and commonly recommended antibacterial agents for the treatment of MRSA-infections are considered inappropriate). Resistance to fluoroquinolones of E. coli – the most common pathogen involved in urinary tract infections – varies across the European Union. Prescribers are advised to take into account the local prevalence of resistance in E. coli to fluoroquinolones. Inhalation Anthrax: Use in humans is based on in vitro Bacillus anthracis susceptibility data and on animal experimental data together with limited human data. Treating physicians should refer to national and/or international consensus documents regarding the treatment of anthrax.

Pregnancy:There are limited amount of data from the use of levofloxacin in pregnant women. Animal studies do not indicate direct or indirect harmful effects with respect to reproductive toxicity (see section 5.3). However in the absence of human data and due to that experimental data suggest a risk of damage by fluoroquinolones to the weight-bearing cartilage of the growing organism, levofloxacin must not be used in pregnant women (see sections 4.3 and 5.3).

Breast-feeding: Levofloxacin Infusion 500mg/100mL is contraindicated in breast-feeding women. There is insufficient information on the excretion of levofloxacin in human milk; however other fluoroquinolones are excreted in breast milk. In the absence of human data and due to that experimental data suggest a risk of damage by fluoroquinolones to the weight-bearing cartilage of the growing organism, levofloxacin must not be used in breast-feeding women (see sections 4.3 and 5.3).

Fertility: Levofloxacin caused no impairment of fertility or reproductive performance in rats.

Side Effects:

Like all medicines, this medicine can cause side effects, although not everybody gets them. These effects are normally mild or moderate and often disappear after a short time. Stop having Levofloxacin Infusion 500mg/100mL and tell a doctor or nurse straight away if you notice the following side effect

Very rare (may affect up to 1 in 10,000 people) 

• You have an allergic reaction. The signs may include: a rash, swallowing or breathing problems, swelling of your lips, face, throat, or tongue Stop having Levocare 500 IV and tell a doctor or nurse straight away if you notice any of the following serious side effects – you may need urgent medical treatment:

Rare (may affect up to 1 in 1,000 people) 

• Watery diarrhoea which may have blood in it, possibly with stomach cramps and a high temperature. These could be signs of a severe bowel problem
• Pain and inflammation in your tendons or ligaments which could lead to rupture. The Achilles tendon is affected most often Fits (convulsions)

Very rare (may affect up to 1 in 10,000 people)

• Burning, tingling, pain or numbness. These may be signs of something called ‘neuropathy’

Other:

• Severe skin rashes which may include blistering or peeling of the skin around your lips, eyes, mouth, nose and genitals 
• Loss of appetite, skin and eyes becoming yellow in colour, dark-coloured urine, itching, or tender stomach (abdomen). These may be signs of liver problems which may include a fatal failure of the liver.

How to Store Levofloxacin Infusion 500mg/100ml:

• Store in a cool dry place below 25C.
• protect from light. 

Why Choose Levofloxacin Infusion 500mg/100ml from Regen Global Pharma?

Levofloxacin Infusion 500mg/100mL from Regen Global Pharma is an excellent choice for several reasons:

• Broad-Spectrum Efficacy: Effective against a wide range of serious bacterial infections, including pneumonia, UTIs, and skin infections, making it versatile in treating various conditions.
• Rapid Action: The intravenous formulation allows for fast absorption and quick therapeutic effects, which is critical in severe or life-threatening infections.
• High-Quality Standards: Manufactured to meet stringent quality standards, ensuring safety, potency, and reliability for healthcare professionals.
• Convenient Dosing: The 500mg/100mL infusion provides an easy-to-administer dose for healthcare providers, ensuring accuracy in treatment.
• Cost-Effective: Offers an affordable alternative for hospitals and healthcare facilities, providing high-quality treatment at a reasonable price.
• Trusted Brand: Regen Global Pharma is known for producing reliable pharmaceutical products, ensuring healthcare providers and patients can trust the medication’s performance.

It’s a fast, reliable, and economical option for treating a variety of bacterial infections in hospitalized patients.

Disclaimer: The information provided on this website is for informational purposes and is not intended as a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified healthcare provider with any questions you may have regarding a medical condition. Do not disregard professional medical advice or delay in seeking it. 

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ABOUT REGEN GLOBAL PHARMA PVT. LTD.:

As one of India’s leading exporters and pharmaceutical manufacturing company in Gujarat, ReGen Global Pharma Pvt. Ltd is committed to global distribution of crucial molecules that advance healthcare solutions worldwide. We have our presence in Togo, Mali, Cameroon, Gambia, Sierra Leone, Burkina Faso, Burundi, Benin Republic, Nigeria, Ghana, Niger, Chad, as well as the Caribbean Island of Guyana, Turkmenistan, and Uzbekistan in Central Asia. 

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